Bioconjugated, Immunological and Synthetic Nanoplatforms for diagnoses and development of new treatments for infectious diseases

Authors

  • Luna R. Gomez Palacios
  • Sofia Martinez
  • Cecilia Tettamanti
  • Daniela Quinteros
  • Guillermo Bracamonte

Abstract

In this communication it was addressed different themes and topics implicated in the development of new treatments and vaccines applied to pathologies developed in humans such as by Virus. In this context, it was presented and discussed different strategies used, which were contemplated from the design of small molecules, towards higher sized chemical structures and new Nanoarchitectures. In particular, it was discussed varied studies developed for the Corona Virus treatment; which afforded to the main mechanisms of action of pharmacophores and targeted functional Nanoparticles. In this direction, it was highlighted the importance of Bioconjugation of molecules and variable Nanoarchitectures for their incorporation within cells and for the development of vaccines. Moreover, it was discussed about the development of combinatory treatments based on different applied strategies. In similar manner, finally it was presented different studies and developments actually in progress related with the design of functional and Multifunctional Nanoarchitectures with potential implications in future treatments.

Author Biographies

  • Luna R. Gomez Palacios

    Instituto de Investigaciones en Físicoquímica de Córdoba (INFIQC). Centro Laser del INFIQC, y Departamento de Química Orgánica del INFIQC, Facultad de Ciencias Químicas, Universidad Nacional de
    Córdoba. Ciudad Universitaria, 5000 Córdoba, Argentina.

  • Sofia Martinez

    Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, 5000 Córdoba, Argentina

  • Cecilia Tettamanti

    Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, 5000 Córdoba, Argentina

  • Daniela Quinteros

    Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, 5000 Córdoba, Argentina

  • Guillermo Bracamonte

    Departement de chimieet Centre d’optique, photonique et laser (COPL), UniversitéLaval, Québec (QC) G1V 0A6, Canada.
    Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, 5000 Córdoba, Argentina

References

1 M. Mousavi, L Tan Moriyama, C. Grecco, et al. Photodynamic therapy dosimetry using multiexcitation multiemission wavelength: toward real-time prediction of treatment outcome J Biomed Opt; 25, 6 (2020) 1-15.

2 Draz MS, Vasan A, Muthupandian A, et al. (2020) Virus detection using nanoparticles and deep neural network-enabled smartphone system. Sci Adv; 6(51): eabd5354:1-. http://dx.doi.org/10.1126/sciadv.abd5354 PMID: 33328239.

3 Morse JS, Lalonde T, Xu S, Liu WR. (2020) Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV. ChemBioChem; 21(5): 730-8. http://dx.doi.org/10.1002/cbic.202000047 PMID: 32022370.

4Amanat F, Krammer F. (2020) SARS-CoV-2 Vaccines: Status ReportImmunity. Cell press; 52: pp. 583-588.

5 Callaway E. (2020) The race for coronavirus vaccines: a graphical guide. Nature; 580(7805): 576-7. http://dx.doi.org/10.1038/d41586-020-01221-y PMID: 32346146.

6 Lipsitch M, Dean NE. (2020) Understanding COVID-19 vaccine efficacy. Science; 370(6518):

763-5. http://dx.doi.org/10.1126/science.abe5938 PMID: 33087460.

7 Walls AC, Fiala B, Schäfer A, et al. (2020) Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2. Cell; 183(5): 1367-1382.e17. http://dx.doi.org/10.1016/j.cell.2020.10.043 PMID: 33160446.

8 Jackson LA, Anderson EJ, Rouphael NG, et al. (2020) An mRNA Vaccine against SARS-CoV-2 — Preliminary Report, The New England Journal of Medicine. N Engl J Med; : 1-12.

9 Ni Q, Zhang F, Liu Y, et al. (2020) A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer. Sci Adv 2020; 6(12): eaaw6071. http://dx.doi.org/10.1126/sciadv.aaw6071 PMID: 32206706.

10 Cohen M S, Corey L. From the Editorial. Combination prevention for COVID-19 Science; 368(6491): 551-552.

11 Drysdale S B, Barr R S, Rollier C S, Green C A, Pollard A J, Sande C J. (2020) Priorities for

developing respiratory syncytial virus vaccines in different target populations Science

Translational Medicine; 12(535): 1-4. http://dx.doi.org/10.1126/scitranslmed.aax2466.

12 Mina MJ, Andersen KG. (2020) COVID-19 testing: One size

13 Ball P. (2021) The lightning-fast quest for COVID vaccines - and what it means for other diseases. Nature; 589(7840): 16-8. http://dx.doi.org/10.1038/d41586-020-03626-1 PMID: 33340018.

14 Das S, Das S, Ghangrekar MM. (2020) The COVID-19 pandemic: biological evolution, treatment options and consequences. Innovative Infrastructure Solutions; 5(76): 1-13.

15 M. J. Christie, A. T. Irving, S. C. Forster, B. J. Marsland, P. M. Hansbro, P. J. Hertzog, C. A. Nold-Petry, M. F. Nold, Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection, Sci. Immunol. 6, eabd0205 (2021) 1- 10.

16 S. A. Rahman, B. Yagnik, A. P. Bally, K. N. Morrow, S. Wang, T. H. Vanderford, G. J. Freeman, R. Ahmed, R. Rao, Amara, PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue, Sci. Immunology, 6, 63 (2021) 1-10.

17 Elzahhar P., Belal A.S.F., Elamrawy F., Helal N.A., Nounou M.I. (2019) Bioconjugation in Drug Delivery: Practical Perspectives and Future Perceptions. In: Weissig V., Elbayoumi T. (eds) Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9516-5_11.

18 Greg T. Hermanson,Chapter 1: Introduction to Bioconjugation.Editor(s): Greg T. Hermanson, Bioconjugate Techniques (Third Edition).Academic Press,2013,Pages 1-125,ISBN 780123822390, https://doi.org/10.1016/B978-0-12-382239-0.00001-7.

19 Iriarte-Mesa, C., López, Y.C., Matos-Peralta, Y. et al. Gold, Silver and Iron Oxide Nanoparticles: Synthesis and Bionanoconjugation Strategies Aimed at Electrochemical Applications. Top Curr Chem (Z) 378, 12 (2020). https://doi.org/10.1007/s41061-019-0275-y.

20 Greg T. Hermanson,Chapter 1: Introduction to Bioconjugation.Editor(s): Greg T. Hermanson, Bioconjugate Techniques (Third Edition).Academic Press,2013,Pages 1-125,ISBN 9780123822390, https://doi.org/10.1016/B978-0-12-382239-0.00001-7.

21 Long NV, Yang Y, Teranishi T, Thi CM, Cao Y, Nogami M. Biomedical Applications of Advanced Multifunctional Magnetic Nanoparticles. J Nanosci Nanotechnol. 2015 Dec;15(12):10091-107. doi: 10.1166/jnn.2015.11691. PMID: 26682455.

22 Lu, L.; Duong, V.T.; Shalash, A.O.; Skwarczynski, M.; Toth, I. Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines. Vaccines 2021, 9, 563. https://doi.org/10.3390/vaccines9060563.

23 Valdes-Balbin, Y.,Santana-Mederos, D.,Quintero, L., ...Garcia-Rivera, D.,Verez Bencomo, V. SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies. ACS Chem. Biol. 2021, 16, 7, 1223–1233 Publication Date:July 4, 2021 https://doi.org/10.1021/acschembio.1c00272.

24 Book entitled: “Frontiers in Nano- and Micro-device Design for Applied Nanophotonics, Biophotonics and Nanomedicine”, Chapters 1-15, authored Book by A.Guillermo Bracamonte, Bentham Science Publishers, ISBN: 978-1-68108-857-0 ©(2021) 1-200. DOI 0.2174/97816810885631210101(https://benthambooks.com/book/9781681088563/

25 Y. Yin, W. Su, J. Zhang, W. Huang, X. Li, H. Ma, M. Tan, M. Tan, M. Tan, H. Song, G. Cao, S. Yu, D. Yu, J. Hoon Jeong, X. Zhao, H. Li, G. Nie, H. Wang, Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19, ACS Nano 2021, 15, 9, 14347–14359.

26 Martin Ame, S. A. Serea, A. Shalan, A. G. Bracamonte, Detection of Viruses and Development of New Treatments: Insights into Antibody-Antigen Interactions and Multifunctional Lab-On- Particle for SARS CoV-2 , J Nanotechnol Nanomaterials, Scientific Archives (Creative Commons Attribution License), 2, 2 (2021) 67-75.

27 C. Salinas, A. G. Bracamonte,From Microfluidics to Nanofluidics and signal Wave-guiding for Nanophotonics, Biophotonics resolution and Drug Delivery, Frontiers in Drug, Chemistry and Clinical Research, 2 (2019) 1-6.

28 Luna R. Gomez Palacios, Alicia Veglia, A. Guillermo Bracamonte, Inflow nano-optics from the near-to the far-field detection based on Metal-Enhanced Fluorescence signaling, Microchemical Journal, 169, 106539 (2021) 1-9.

29 J. Guo, K. Feng, W. Wu, Y.Ruan, H. Liu, X. Han, G. Shao, X. Sun, Smart I-Labeled Self- Illuminating Photosensitizers for Deep Tumor Therapy, Angewandte Chemie International, 60, 40 (2021) 21884-21889. https://doi.org/10.1002/anie.2021072.

30 T. L.Wiemken, J. Salas, D. F.Hoft, C.Jacobs, J. E.Morley, J. F.Scherrer, Dementia risk following influenza vaccination in a large veteran cohort, Vaccine, 39, 39 (2021)5524-5531.

Downloads

Published

2022-04-18