Inflammation in the XXI century, from classical concepts to a more extended view
PDF (Espanhol)
HTML (Espanhol)

Palavras-chave

inflamação
interações neuroimunoendócrinas
metabolismo

Como Citar

Bottasso, O. (2022). Inflammation in the XXI century, from classical concepts to a more extended view. Pinelatinoamericana, 2(2), 116-124. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/38192

Resumo

O artigo refere-se aos diversos mecanismos que desencadeiam a resposta inflamatória e as consequências que costumam ocorrer quando a agente nocivo não é esclarecida com a perpetuação do processo; que está ligado à interligação entre os principais sistemas do corpo: imunológico, endócrino e o sistema nervoso autônomo. Em consonância com as pesquisas mais recentes, uma nova abordagem também é oferecida, onde a inflamação se torna uma resposta destinada a restaurar a homeostase. Existe um componente associado a desvios excessivos dos processos celulares, incapazes de ser controlados por mecanismos reguladores, que possui algumas, mas não todas as características da resposta clássica: para ou metaflamação. Por outro lado, a inflamação tradicional, que, embora possa estar relacionada com este fenómeno, está particularmente ligada à resposta a agentes patogénicos, toxinas ou outros agentes, não ajustáveis em si, mas igualmente ameaçadores.

PDF (Espanhol)
HTML (Espanhol)

Referências

Andhavarapu, S., Mubariz, F., Arvas, M., Bever, C., Jr, y Makar, T. K. (2019). Interplay between ER stress and autophagy: A possible mechanism in multiple sclerosis pathology. Experimental and molecular pathology, 108, 183–190. https://doi.org/10.1016/j.yexmp.2019.04.016

Brewer, S. M., Brubaker, S. W., y Monack, D. M. (2019). Host inflammasome defense mechanisms and bacterial pathogen evasion strategies. Current opinion in immunology, 60, 63–70. https://doi.org/10.1016/j.coi.2019.05.001

Dantzer R. (2009). Cytokine, sickness behavior, and depression. Immunology and allergy clinics of North America, 29(2), 247–264. https://doi.org/10.1016/j.iac.2009.02.002

Das, U. N., (2022). Papel de los Lípidos Bioactivos en Psiquiatría, Inmunología, Neurología y Endocrinología (PINE). Pinelatinoamericana, 2(1), 56–81. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/37046

D'Attilio, L., Santucci, N., Bongiovanni, B., Bay, M. L., y Bottasso, O. (2018). Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology. Frontiers in endocrinology, 9, 214. https://doi.org/10.3389/fendo.2018.00214

Evans, W. J., Morley, J. E., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-Zadeh, K., Lochs, H., Mantovani, G., Marks, D., Mitch, W. E., Muscaritoli, M., Najand, A., Ponikowski, P., Rossi Fanelli, F., Schambelan, M., Schols, A., Schuster, M., Thomas, D., Wolfe, R y Anker, S. D. (2008). Cachexia: a new definition. Clinical nutrition (Edinburgh, Scotland), 27(6), 793–799. https://doi.org/10.1016/j.clnu.2008.06.013

Ganeshan, K., y Chawla, A. (2014). Metabolic regulation of immune responses. Annual review of immunology, 32, 609–634. https://doi.org/10.1146/annurev-immunol-032713-120236

González, F. B., Villar, S. R., Pacini, M. F., Bottasso, O. A., y Pérez, A. R. (2020). Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology. Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165642. https://doi.org/10.1016/j.bbadis.2019.165642

Hotamisligil G. S. (2006). Inflammation and metabolic disorders. Nature, 444(7121), 860–867. https://doi.org/10.1038/nature05485

Kotas, M. E., y Medzhitov, R. (2015). Homeostasis, inflammation, and disease susceptibility. Cell, 160(5), 816–827. https://doi.org/10.1016/j.cell.2015.02.010

Kusminski, C. M., Bickel, P. E., y Scherer, P. E. (2016). Targeting adipose tissue in the treatment of obesity-associated diabetes. Nature reviews. Drug discovery, 15(9), 639–660. https://doi.org/10.1038/nrd.2016.75

Man, S. M., Karki, R., y Kanneganti, T. D. (2017). Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunological reviews, 277(1), 61–75. https://doi.org/10.1111/imr.12534

Medzhitov R. (2021). The spectrum of inflammatory responses. Science (New York, N.Y.), 374(6571), 1070–1075. https://doi.org/10.1126/science.abi5200

Matsuzawa-Ishimoto, Y., Hwang, S., y Cadwell, K. (2018). Autophagy and Inflammation. Annual review of immunology, 36, 73–101. https://doi.org/10.1146/annurev-immunol-042617-053253

Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N., y Crowe, S. M. (2015). Glucose metabolism regulates T cell activation, differentiation, and functions. Frontiers in immunology, 6, 1. https://doi.org/10.3389/fimmu.2015.00001

Rohm, T. V., Meier, D. T., Olefsky, J. M., y Donath, M. Y. (2022). Inflammation in obesity, diabetes, and related disorders. Immunity, 55(1), 31–55. https://doi.org/10.1016/j.immuni.2021.12.013

Russell, D. G., Huang, L., y VanderVen, B. C. (2019). Immunometabolism at the interface between macrophages and pathogens. Nature reviews. Immunology, 19(5), 291–304. https://doi.org/10.1038/s41577-019-0124-9

Sugimoto, M. A., Vago, J. P., Perretti, M., y Teixeira, M. M. (2019). Mediators of the Resolution of the Inflammatory Response. Trends in immunology, 40(3), 212–227. https://doi.org/10.1016/j.it.2019.01.00 7

Takeuchi, O., y Akira, S. (2010). Pattern recognition receptors and inflammation. Cell, 140(6), 805–820. https://doi.org/10.1016/j.cell.2010.01.022

Talbot, S., Foster, S. L., y Woolf, C. J. (2016). Neuroimmunity: Physiology and Pathology. Annual review of immunology, 34, 421–447. https://doi.org/10.1146/annurev-immunol-041015-055340

Zindel, J., y Kubes, P. (2020). DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. Annual review of pathology, 15, 493–518. https://doi.org/10.1146/annurev-pathmechdis-012419-032847

Creative Commons License

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2022 Pinelatinoamericana

Downloads

Download data is not yet available.