Amoniuria, gap urinario y osmolal en pacientes con insuficiencia renal moderada
DOI:
https://doi.org/10.31053/1853.0605.v69.n3.21122Palabras clave:
Amonio Urinario (NH4 u), GAP urinario, Cl Cr y MDRD6Resumen
La acidosis metabólica crónica induce incremento en la producción de amonio urinario (NH4+u) como mecanismo compensador, reflejado en mayor o menor medida, si el proceso es crónico o agudo. El objetivo del presente trabajo fue estudiar la capacidad de acidificación urinaria en pacientes con Fracaso Renal Crónico (FRC), estadío II y III midiendo NH4+u y comparar resultados con GAP urinario (GAPu),GAP urinario modificado (GAPu mod), GAP Osmolal (GAPosm) y GAP Osmolal modificado (GAPosm modif.) como índices indirectos de la amoniuria. Se analizaron muestras de sangre venosa/arterial y orina fresca minutada de 34 pacientes. Se obtuvo correlación estadísticamente significativa (p < 0,003) entre NH4+u ug/min/1.73m2 vs GAPu mmol/l (r = -0,4979) y GAPu mod mmol/l (-0,5032), mejorando cuando NH4+u se normatizó por creatinina (r = - 0,6793 y 0,6087 respectivamente, p < 0,0001). El GAPosm y GAPosm modif no mostraron significancia a la hora de evaluar NH4+u, contrariamente GAPu y GAPu mod ofrecerían una medida indirecta de excreción de NH4+u, dando este último información nutricional proteica. Se consideró estadísticamente significativo un valor de p< 0.05.Descargas
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