Respuesta inadecuada a la vacuna contra la hepatitis B en personal de salud del Hospital Nacional, Paraguay

  • Raúl Emilio Real Delor Dpto. de Medicina Interna. Hospital Nacional. Itauguá, Paraguay http://orcid.org/0000-0002-5288-5854
  • Gustavo Villar Postgrado en Medicina Interna. Universidad Nacional de Itapúa
  • Julia Rigel Espínola Dpto. de Laboratorio. Hospital Nacional. Itauguá
Palabras clave: vacuna hepatitis B, antiHBs, personal de salud

Resumen

Introducción: el personal de salud es un grupo de riesgo de adquirir la hepatitis B. La vacuna contra la misma es efectiva pero requiere evaluación de la respuesta inmune con el dosaje de antiHBs.

Objetivos: determinar la respuesta inmunológica a la vacuna contra la hepatitis B en médicos, enfermeras y estudiantes de Medicina del Hospital Nacional, Paraguay.

Métodos: se realizó un estudio observacional, analítico y transversal en una muestra de 120 trabajadores de la salud durante el 2017. Se determinó el nivel de antiHBs con inmunoensayo cuantitativo y se registraron variables demográficas y clínicas, previo consentimiento informado.

Resultados: la muestra se conformó con 79 mujeres y 41 varones. La edad media fue 30±8 años. Se incluyeron médicos (62,5%), enfermeras (20%) y estudiantes de Medicina (17,5%). El IMC medio fue 24,7±3,8 kg/m2. Los niveles séricos adecuados de antiHBs (>100 UI/mL) se detectaron en 64% del personal de salud. La obesidad fue un factor asociado a mala respuesta a la vacuna (p 0,02). El sexo, la edad, el tiempo trascurrido desde la última dosis y el tabaquismo no resultaron factores significativamente asociados a la falta de respuesta a la vacuna.

Conclusión: la respuesta inadecuada a vacuna HB se halló en 36%. La obesidad se asoció significativamente a la mala respuesta inmunológica.

Biografía del autor/a

Raúl Emilio Real Delor, Dpto. de Medicina Interna. Hospital Nacional. Itauguá, Paraguay

Jefe del Dpto. de Medicina Interna del Hospital Nacional, Itauguá, Paraguay

Coordinador del Postgrado en Medicina Interna, Facultad de Medicina, Universidad Nacional de Itapúa, Paraguay

Citas

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Publicado
2018-09-02
Sección
Artículos Originales