Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary
Keywords:
salivary tumors, mucoepidermoid carcinoma, histological grade, MUC-1, Ki67Abstract
Background: Salivary gland tumors are rare and with different malignant potential. Immunohistochemistry is useful, especially Ki67, a marker of cell proliferation, for its prognostic information. On the other side, the mucin MUC-1 is overexpressed and loses its exclusively apical membranous localization and is aberrantly glycosylated in mucoepidermoid carcinoma of salivary glands. In the present work, we investigated the quantitative expression of tumor proliferative index and localization and overexpression of MUC-1 in the mucoepidermoid carcinoma of the human salivary glands, not studied is these organs, to determine their relationship with the histological grade and prognosis. Methods: H/E staining and immunohistochemistry with MUC-1 and Ki67 antibodies was performed on 10 cases. Results: The markings of the mucoepidermoid carcinoma depended on the histological grade; in low- grade tumors with MUC-1 only 10 to 25% of the cells were labeled, in contrast to high- grade tumors, with 75 to 90% labeled cells. They also differed in cell proliferation; in the low-grade tumors was 15% and in high-grade tumors it was greater than 30%. Conclusion: MUC-1 overexpression is significantly higher in high-grade mucoepidermoid carcinoma, as is Ki67 marking, results that are associated with tumor prognosis
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References
Ellis GL, Auclair PL. Tumors of salivary glands. Washington, DC: American Registry of Pathology Armed Forces Institute of Pathology, 2008.
Menghi E, Kara CO, Tumkaya F, Ardic FN, Bir F. Salivary gland tumors: A 15 years of experience of a university hospital in Turkey. North Clin Istanb 2020; 7: 366-71.
Bussari S, Ganvir SM, Sarode M, Jeergal PA, Deshmukh A, Srivastava H. Immunohistochemical detection of proliferative marker ki-67 in benign and malignant salivary gland tumors. J Contemp Dent Pract 2018; 19:375-83.
García PE, Samar ME, Avila RE. Le marqueur Ki67 dans les tumeurs des glandes salivaires. Signification pronostique: Etude clinicopathologique. Republic of Moldova: Edition Natre Savoir. Sciencia Scripts. Dodo Books Indian Ocean, 2021.
Menon SS, Guruvayoorappan C, Sakthivel KM, Rasmi RR. Ki-67 protein as a tumour proliferation marker. Clin Chim Acta 2019; 491: 39-45. doi: 10.1016/j.cca.2019.01.011.
Kho HS. Oral epithelial MUC-1 and oral health. Oral Dis. 2018; 24: 19-21.
Kashyap B, Kullaa AM. Regulation of mucin 1 expression and its relationship with oral diseases. Arch. Oral Biol 2020; 117. 104791. http://doi.org/10.1016/j.archoralbio.2020.104791
Syrkina MS, Vassetzky YS, Rubtsov MA. MUC1 story: great expectations, disappointments and the renaissance. Curr. Med. Chem 2019; 24: 1-10.
Ma S, An F, Li LH, Lin YY, Wang J. Expression of Mucin 1 in salivary glands tumors and its correlation with clinicopathological factors. J Biol Regul Homeost Agents 2019; 33: 563-9.
Pedroza de Andrade E, Novaes Teixeira L, Martins Montalli VA, de Melo Garcia F, Passador-Santos F, Borges Soares A, Cavalcanti de Araújo V. Epithelial membrane antigen and DOG1 expression in minor salivary gland tumours. Ann Diagn Pathol 2019; 43:151408. doi: 10.1016/j.anndiagpath.2019.151408.
Lau SK, Weiss LM, Chu PG. Differential expression of MUC-1, MUC-2 and MUC-5AC in carcinomas of various sites. An immunohistochemical study. Am J Clin Pathol 2004; 122: 61-9.
Alos L, Luján B, Castillo M, Nadal A, Carreras M, Caballero M, Bolos C, Cardesa A. Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC-2, MUC-5AC, MUC-5B, MUC-6, and MUC-7) in mucoepidermoid carcinomas of salivary glands. Am J Surg Pathol 2005; 29: 806-13. doi: 101097/01.pas.000015585684553.c9.
Borges Soares A, Dias Demasi AP, Altemani A, Cavalcanti de Araújo V. Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. Histopathology 2011; 58: 377-82.
Ferreira Gonçalves C, Oliveira Morais M, Gonçalves Alencar R. de C, Duarte Mota E, Silva TA, Carvalho Batista A, Mendonça EF. Expression of Ki 67 and MUC-1 in mucoepidermoid carcinomas in young and adult patients: prognostic implications. Exp Mol Pathol 2011; 90: 271-5. doi: 10.1016/j.yexmp.2011.01.007.
Kusafuka K, Ueno T, Kurihara K, Murata T, Yurikusa T, Henmi H, Akane M, Ota Y, Kameya T. Cystadenoma of the palate: immunohistochemistry of mucins. Pathol Int 2008; 58: 524-8.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, Van Heerden WFP. Expression of mucins in salivary gland mucoepidermoid carcinoma. Head Neck Pathol 2021; doi: 10.1007/s12105-020-01226-z.
Li S, Liu S, Ruan Mi Yang W Wang L, Zhang C. Increased expression of MUC-1 has close relation with patient survivor in high-grade salivary gland mucoepidermoid carcinoma. J Oral Pathol Med 2014; 43: 579-84.
Gomez Rosso MA, Samar ME, Ávila RE, Ferraris L, Fonseca I, Fernández JE. Adenoma pleomórfico de glándula lagrimal: localización atípica de un tumor salival. Rev Fac Odont 2020; 30: 20-8.
Samar Romani ME, Avila Uliarte RE, García Esst PE, Fonseca Acosta IB, Fernández Calderón JE. Expresión de KI67 y MUC1 en el adenocarcinoma no especificado de otra manera (NOS) de glándulas salivales: presentación de 2 casos y su importancia pronóstica. Int J Odontoestomatol 2020; 14: 407-16
World Health Organization. Classification of Head and Neck Tumours. Volume 9. 4th ed. Lyon: Edited by El-Naggar A.K., Chan J.K.C., Grandis J.R., Takata T. y Slootweg J. IARC Press, 2017.
Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 1992; 69 (8):2021-30.
Langner C, Ratschek M, Rehak P, Schips L, Zigeuner R. Expression of MUC-1 (EMA) and E-cadherin in renal cell carcinoma: a systematic immunohistochemical analysis of 188 cases. Mod Pathol 2004; 17: 180-8.
Li LT, Jiang G, Zheng JN. Ki67 is a promising molecular target in the diagnosis of cancer. Mol Med Reports 2015; 11: 1566-72. doi: 10.3892/mmr.2014.2914.
Peraza A, Gómez R, Beltran J, Amarista FJ. Mucoepidermoid carcinoma. An update and review of the literature. J Stomatol Oral Maxillofac Surg 2020; 121: 713-720.doi: 10.1016/j.jormas. 2020.06.003
Avila RE, Samar ME, Ferraris R, La Rosa F. Oncocytic mucoepidermoid carcinoma of the submandibular salivary gland: A challenging differential diagnosis of a very rare tumor. Ann Clin Case Rep 2019; 4: Article 1728.
Shafique K, Zhang PJ, Montone KT, Song S, LiVolsi VA, Baloch Z. Pathologic grading of mucoepidermoid carcinomas of the salivary gland and its effect on clinicopathologic follow-up: an institutional experience. Human Pathol 2020; 98: 89-97. doi: 10.1016/j.humpath.2020.02.001.
Batsakis JG, Luna MA. Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol 1990; 99: 835–8.
Leivo I. Insights into a complex group of neoplastic disease: advances in histopathologic classification and molecular pathology of salivary gland cancer. Acta Oncol 2006; 45: 662-8.
Higgins KE, Cipriani NA. Practical immunohistochemistry in the classification of salivary gland neoplasms. Semin Diagn Pathol 2022; 39: 17-28. doi: 10.1053/j.semdp.2021.10.004.
Živković N, Kostić M, Cvetanović A, Jovičić Milentijević M, Spacić M, Petrović M, Trajković M, Denčić T, Krtinić D. Differential challenges in salivary gland neoplasms. Arch Biol Sci 2021; 73: 65-72. http://dx.doi.org/10.2298/ABS201201002Z
Bhatia R, Gautam SK, Cannon A , Thompson C, Hall BR, Aithal A, Banerjee K, Jain M, Solheim JC, Kumar S, Batra SK. Cancer-associated mucins: role in immune modulation and metastasis. Cancer Metastasis Rev 2019; 38:223-36. doi: 10.1007/s10555-018-09775-0.
Ganguly K, Rauth S, Marimuthu S, Kumar S, Batra SK. Unraveling mucin domains in cancer and metastasis: when protectors become predators. Cancer Met Rev 2020; 39: 647-59. doi: 10.1007/s10555-020-09896-5.
Wagner CE, Wheeler KM, Ribbeck K. Mucins and their role in shaping the functions of mucous barrier. Annu Rev Cell Dev Biol 2018; 34: 189-215. http://doi.org/10.1146/annurev-cellbio-100617-062818.
Nath S, Mukherjee P. MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends Mol Med 2014; 20: 32-42. doi: 10.1016/j.molmed.2014.02.007.
Chen W, Zhang Z, Zhang S, Zhu P, Shun Ko JK, Lam Yung KK, Nees M. MUC1: Structure, function, and clinic application in epithelial cancers. Int J Mol Sci 2021; 22: 6567. doi: 10.3390/ijms22126567.
Shemirani N, Osipov V, Kolker A, Khampang P, Kerschner JE. Expression of mucin (MUC) genes in mucoepidermoid carcinoma. Laryngoscope 2011; 121: 167-70.
Isaka E, Sugiura T, Hashimoto K, Kikuta K, Anazawa U, Nomura T, Kameyama A. Characterization of tumor-associated MUC1 and its glycans expressed in mucoepidermoid carcinoma. Oncol Let 2021; 22:702. doi: 10.3892/ol.2021.12963.
Siyi L, Shengwen L, Min R, Wenjun Y, Lizheng W, Chenping Z. Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma. J Cran Maxillofac Surg 2014; 42: 1891-6. http://dx.doi.org/10.1016/j.jcms.2014.07.008
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