Evaluation of different treatments of chronic and severe periodontitis in adult patients: meta-analysis of clinical trials

Alejandra Bono et al.


Chronic periodontitis is the most frequent type of periodontitis in the population. For its treatment, traditional mechanical methods are applied, such as scraping and root smoothing. Currently, the newest methods that apply antimicrobials, bactericides or lasers are used in combination with traditional methods. The results of clinical trial publications are contradictory about the best therapy to treat chronic periodontitis, so it is necessary to determine the evidence on this subject. The objective of this study was, therefore, to evaluate different treatments for chronic and severe periodontitis in adults through a meta-analysis of clinical trials. This study followed PRISMA guidelines to carry out the meta-analysis of randomized clinical trial studies and MEDLINE, EMBASE, Scielo Cochrane and Scopus databases, between July 30, 2016 and July 30, 2017. The meta-analysis was performed using the standardized mean difference (DME). Heterogeneity was tested using the Q test and the I2 statistic, using the meta-package - R 3.4.3 (2017). Measurements of insertion loss, depth of probing, bleeding rate and plaque index showed high heterogeneity, therefore the studies were grouped according to the type of treatment patients received (physical or bactericidal methods) for each variable, by what the heterogeneity of some variables decreased

Palabras clave

periodontitis, meta-analysis, treatment

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